High Shear Mixer Granulator 2 Min Dry Mix 1-4 Min Granulating 50kg Batch

Wet granulation is usually limited by the mixer, not by the drying step. The GHL-200 high shear mixer granulator completes dry mixing in about two minutes and granulating in one to four minutes, so a full 50 kg batch of tablet granulate is ready for the fluid bed dryer within a single short cycle. A plough share impeller turns the powder into a fast moving vortex while a separate chopper breaks the wetted mass into uniform granules, which is why the high shear mixer granulator delivers a repeatable granule size instead of the wide spread produced by a low shear paddle mixer.

The horizontal barrel is polished internally with no dead corner and runs sealed, in line with GMP requirements for solid dosage production. Because the binder is distributed mechanically rather than by long tumbling, the high shear mixer granulator uses about 25% less binder solution than a conventional process and leaves the wet mass with less moisture, which shortens the following drying step and protects heat sensitive actives. Even when the active ingredient and the excipient differ widely in particle size or bulk density, the vortex keeps both phases together and no delamination is seen in the finished granule.

• 2 Minute Dry Mix, 1 to 4 Minute Granulating: a complete wet granulation cycle is finished in five to six minutes, four to five times faster than a traditional mixer plus tray process, so one high shear mixer granulator can feed several dryers.
• 25 Percent Binder Saving: mechanical shear distributes the binder solution evenly at lower liquid addition, cutting binder cost and reducing the drying load on the downstream fluid bed dryer.
• Uniform Granule, No Delamination: the plough share vortex keeps heavy and light components in suspension, so a granule with a 20 to 80 mesh size range stays homogeneous even when the active load is low.
• Sealed GMP Barrel: horizontal cylindrical or conical barrel options, polished inner surface free of dead corners, sealed discharge and a wash down design that supports validated cleaning between products.
• Dual Speed Drive: the mixing shaft runs at 30 or 300 rpm and the chopper at 1500 or 3000 rpm, so the same high shear mixer granulator handles a fragile granule and a dense wet mass without mechanical change.
• Operator Safety Interlock: the discharge valve, the top cover and the drive are interlocked, so the impeller cannot start with the cover open and the chopper stops before the discharge flap opens.

The high shear mixer granulator is the standard wet granulation unit wherever a dense, free flowing granule is needed before drying or tableting:

1. Tablet and capsule granulate in solid dosage plants, feeding a fluid bed dryer or a tray oven directly.
2. Food powder agglomeration such as instant soup base, cocoa drink mix and seasoning blend.
3. Chemical and agrochemical wet granulation where dust control and granule strength are both required.
4. Detergent and catalyst carrier granulation with low binder addition and a narrow granule size band.
5. Laboratory and pilot formulation work where the same geometry scales to the production model.

Because the high shear mixer granulator closes the barrel during processing, solvent wetted and potent compounds are handled without dust release into the room, which simplifies containment and shortens the cleaning cycle between campaigns.

Is a five minute cycle realistic for a 50 kg batch? Yes. Dry mixing takes about 2 minutes, binder addition and wet massing take 1 to 4 minutes, and discharge adds less than a minute. The four to five times gain over a traditional process comes from mechanical shear, not from a larger motor.

How does the high shear mixer granulator save 25% binder? The impeller creates a high shear field that spreads the binder over every particle within seconds, so less liquid is needed to reach the same granule strength. Less liquid also means a shorter drying time in the next stage.

What granule size can be produced? The standard configuration produces granules in the 20 to 80 mesh range by adjusting chopper speed, binder addition rate and wet massing time. A finer granule is obtained at higher chopper speed and shorter wet massing.

Will a light active ingredient separate from a dense excipient? No. The vortex keeps the whole bed in motion, so a low dose active stays evenly distributed and the finished granule shows no delamination in a content uniformity test.

The high shear mixer granulator ships as a single welded unit on a steel frame inside an export plywood case, with the control panel and the chopper shaft packed separately. Balancing of the impeller, a no load run test, weld inspection, surface roughness report and material certificates are supplied with each unit. The warranty covers 12 months of operation, and a two year spare kit with shaft seals, discharge seals and chopper blades is available together with installation and validation support.